The Carlton & Grand Canal is located along the famous Grand Canal. The attractions of central Venice are within 10 minutes walking distance of the hotel, including the Jewish Quarter, Rialto Bridge, and the Piazzale Roma. The Hotel Carlton & Grand Canal has airport transfers available, as Venice International is only 6 km away. The hotel also faces Santa Lucia Station, and is 50 meters from the nearest waterbus stop.

The Hotel Carlton on the Grand Canal Venice, has 150 rooms, decorated in an 18th century Venetian influenced style. Some rooms overlook the Grand Canal, while others overlook an interior courtyard. Last renovated in 2001, rooms have en-suite bathrooms, high-speed Internet, satellite TV, and air conditioning.

The Carlton & Grand Canal Venice is known for having more than 100 windows that overlook the Grand Canal, as well as conference space for up to 60 people. Architecturally it is very much in the Venetian style, with Murano glass accents and glass cupola illuminating the reception area. Rendez Vous is the daytime snack bar, which coverts to a piano lounge at night.